Oxidative trifluoromethoxylation reaction of C-H bond
A scientific team used palladium to catalyze the oxidative trifluoromethoxylation reaction of the CH bond at the allyl position. Under mild conditions, CsOCF3, which has good stability and poor solubility, was used as the source of trifluoromethoxy, in the presence of AgBF4 Next, benzoquinone is used as an oxidant to slowly release AgOCF3 in the reaction, avoiding the problem of a large amount of decomposition when AgOCF3 is added at the beginning of the reaction. It can synthesize allyl trifluoromethoxy ether compounds with high selectivity. Provide an efficient preparation method.
3-Fluoropyridine-2-carboxylic acid CAS:152126-31-3
3,5-Difluorophenylboronic acid CAS:156545-07-2